The Nebraska Panhandle is an area in the western part of the state of Nebraska and one of several U.S. state panhandles, or elongated geographical regions that extend from their main political entity.

The Nebraska panhandle is two-thirds as broad as the rest of the state. It is approximately 100 miles (160 km) east to west and 125 miles (200 km) north to south. The Nebraska panhandle roughly encompasses the area in Nebraska between 102° and 104°W longitude and 41° and 43°N latitude. It comprises 11 counties with a combined land area of 14,181 square miles (36,730 km²), or about 18.45 percent of the state's land. Its population as of the 2010 Census was 87,789 inhabitants, or about 4.70 percent of the state's population. Its largest city is Scottsbluff, in the west-central part of the area.